THE PLURIPOTENCY TRANSCRIPTION FACTOR NANOG REPRESSES GLUTATHIONE REDUCTASE GENE EXPRESSION IN MOUSE EMBRYONIC STEM CELLS

The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells

Abstract Objective Redox homeostasis maintenance is essential to bring about cellular functions.Particularly, embryonic stem cells (ESCs) have high fidelity mechanisms for DNA repair, high activity of different antioxidant enzymes and low levels of oxidative stress.Although the expression and activity of antioxidant enzymes are reduced throughout t

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